Sodium Cyanide → 4-amino-1-methylpiperidine-4-carbonitrile

HRID 264019

反応式

HRID 264019 の反応式
[OH-].[NH4+:2].[Cl-].[NH4+:4].[C-:5]#N.[Na+].[CH3:8][N:9]1[CH2:14][CH2:13][CH2:12][CH2:11][C:10]1=O>>[NH2:2][C:12]1([C:5]#[N:4])[CH2:13][CH2:14][N:9]([CH3:8])[CH2:10][CH2:11]1

参加物

5

反応物 4

HCID 8929Sodium CyanideHCID 13603N-Methyl-2-piperidoneHCID 14923Ammonium HydroxideHCID 25517Ammonium Chloride

生成物 1

HCID 114349914-amino-1-methylpiperidine-4-carbonitrile

実験手順

Using the procedure of Stage 1 of Example 1, 8 ml of ammonium hydroxide, 1.58 g of ammonium chloride and 1.23 g of sodium cyanide were reacted and 2.5 ml of 1-methylpiperidone were added. The mixture was stirred for 18 hours at ambient temperature, followed by extraction r3 times with chloroform. The organic phase was washed with salt water and dried to obtain 2.41 g of the expected product (orange-yellow syrup).

後処理

  1. customwere reacted
  2. extractionfollowed by extraction r3 times with chloroform
  3. washThe organic phase was washed with salt water
  4. customdried

出典と根拠

ORDレコード
ord-dc5971b1cb52476e8660ccef912bd5c0
出典データセット
uspto-grants-1997_07
特許番号
US05646172

関連ノート

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