化工社化工社 化学情報印刷レポート · 研究参考用
Triethylamine → ethyl (+/-)-5-decyl-alpha-phenyl-2H-tetrazole-2-acetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Ethyl 2-(2-bromophenyl)acetate | HCID 2780092 | — |
| 反応物 | HCID 178442802 | HCID 178442802 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | ethyl (+/-)-5-decyl-alpha-phenyl-2H-tetrazole-2-acetate | HCID 19391039 | 34% |
反応手順
The 5-decyl-1H-tetrazole, (4.0 g, 0.019 mol), triethylamine (2.9 mL, 0.021 mol) and ethyl 2-bromophenylacetate (5.09 g, 0.021 mol) were dissolved in 200 mL acetonitrile and heated to reflux for 2 hours. Cooled and concentrated in vacuo to give a yellow oil. Chromatography to separate the regioisomers gave ethyl (±)-5-decyl-α-phenyl-2H-tetrazole-2-acetate as a clear oil (2.40 g, 34%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05646170 |
| 出典データセット | uspto-grants-1997_07 |
| ORD ID | ord-2ea9bf9706214eb78de91b345ae6e45e |
| 出典メモ | uspto-grants-1997_07 |