Phosgene → 2,4,6-Trimethoxyphenyl isocyanate
反応式
Cl.[CH3:2][O:3][C:4]1[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=[C:7]([O:13][CH3:14])[C:5]=1[NH2:6].[C:15](Cl)(Cl)=[O:16]>C1(C)C=CC=CC=1>[CH3:14][O:13][C:7]1[CH:8]=[C:9]([O:11][CH3:12])[CH:10]=[C:4]([O:3][CH3:2])[C:5]=1[N:6]=[C:15]=[O:16]参加物
4
反応条件
- 温度
- 95 °C
実験手順
A suspension of 2,4,6-trimethoxyaniline hydrochloride (71.1 g, 0.324 mol) in a 12.5% wt/wt solution (540 mL) of phosgene in toluene was heated (95° C.) for 3 hours. Additional phosgene solution (2×270 mL) was added every hour. The mixture was allowed to cool and stirred under house vacuum for 2 days. The mixture was rotoevaporated to a solid. The solid was triturated with ether (450 mL), filtered, and the filtrate rotoevaporated to give a purple amorphous solid; yield 66.9 g (99%); mp 67°-70° C.
後処理
- temperatureto cool
- customThe solid was triturated with ether (450 mL)
- filtrationfiltered
- customto give a purple amorphous solid
出典と根拠
- ORDレコード
- ord-5969808b102e47f59394521fcbadd3ba
- 出典データセット
- uspto-grants-1997_07
- 特許番号
- US05646170
反応ノート
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