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alpha-Angelica lactone → 3-acetonyl-4-(3-methoxyphenyl)-1,5,6,7-tetrahydro-2H-azepinone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | alpha-Angelica lactone | HCID 11559 | — |
| 反応物 | 5-(3-methoxyphenyl)-3,4-dihydro-2H-pyrrole | HCID 12009051 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 3-acetonyl-4-(3-methoxyphenyl)-1,5,6,7-tetrahydro-2H-azepinone | HCID 20332934 | — |
反応手順
The starting material is prepared as follows: The solution of 70 g of 2-(3-methoxyphenyl)-1-pyrroline [J. Org. Chem. 23, 1278, 1281 (1958)] and 43.2 g of α-angelicalactone in 600 ml of toluene is refluxed overnight. A second portion of 43.2 g of α-angelicalactone is added, the mixture is again refluxed overnight, cooled and evaporated. The residue is crystallized from 50 ml of ethyl acetate, to yield the 3-acetonyl-4-(3-methoxyphenyl)-1,5,6,7-tetrahydro-2H-azepinone, melting at 140°-142°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04150129 |
| 出典データセット | uspto-grants-1979_04 |
| ORD ID | ord-811a6d3800664a58b1f7f400a25bf363 |
| 出典メモ | uspto-grants-1979_04 |