1,2,3,6-Tetrahydropyridine → HCID 178501988、化合物

HRID 26441

反応式

HRID 26441 の反応式
Cl[C:2]1[N:7]=[C:6]([NH:8][C:9]([O:11][CH3:12])=[O:10])[N+:5]([O-:13])=[C:4]([NH:14][C:15]([O:17][CH3:18])=[O:16])[CH:3]=1.[NH:19]1[CH2:24][CH2:23][CH:22]=[CH:21][CH2:20]1>C(Cl)Cl>[N:19]1([C:2]2[N:7]=[C:6]([NH:8][C:9]([O:11][CH3:12])=[O:10])[N+:5]([O-:13])=[C:4]([NH:14][C:15]([O:17][CH3:18])=[O:16])[CH:3]=2)[CH2:20][CH:21]=[CH:22][CH2:23][CH2:24]1

参加物

4

反応物 2

HCID 127501,2,3,6-TetrahydropyridineHCID 178501976HCID 178501976、化合物

生成物 1

HCID 178501988HCID 178501988、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A suspension of 10 g. of dimethyl 6-chloro-2,4-pyrimidine-dicarbamate-3-oxide in 40 ml. of methylene chloride is treated with 20 ml. of 1,2,5,6-tetrahydropyridine and stirred at room temperature under an argon atmosphere for 16 hours. The resulting precipitate is filtered off and recrystallized from a mixture of methylene chloride and methanol, there being obtained pure dimethyl 6-[3,6-dihydro-1(2H)-pyridyl]-2,4-pyrimidine-dicarbamate-3-oxide, having a melting point of 203° C.

後処理

  1. additionA suspension of 10 g
  2. filtrationThe resulting precipitate is filtered off
  3. customrecrystallized from a mixture of methylene chloride and methanol, there

出典と根拠

ORDレコード
ord-6f35217b07ba4090a7957fb0a6b3854f
出典データセット
uspto-grants-1979_04
特許番号
US04150132

関連ノート

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