N-(2-aminoethyl)acetamide → N-[2-(7-methoxy-1,4-dihydro-indeno[1,2-b]pyrrol-1-yl)-ethyl]-acetamide
反応式
O=[CH:2][CH2:3][CH:4]1[CH2:12][C:11]2[C:6](=[CH:7][C:8]([O:13][CH3:14])=[CH:9][CH:10]=2)[C:5]1=O.[C:16]([NH:19][CH2:20][CH2:21][NH2:22])(=[O:18])[CH3:17]>C1(C)C=CC=CC=1>[CH3:14][O:13][C:8]1[CH:7]=[C:6]2[C:11]([CH2:12][C:4]3[CH:3]=[CH:2][N:22]([CH2:21][CH2:20][NH:19][C:16](=[O:18])[CH3:17])[C:5]=32)=[CH:10][CH:9]=1参加物
4
実験手順
A solution of 4.5 g of (RS)-2-(2-oxoethyl)-6-methoxy-1-indanone and 2.3 g of N-acetylethylenediamine in 100 ml of toluene was boiled under reflux for 10 minutes. The reaction mixture was evaporated in a vacuum, taken up in dichloromethane, dried with magnesium sulfate and again evaporated. After purification on silica gel (ethyl acetate), 0.9 g (15%) of N-[2-(7-methoxy-1,4-dihydro-indeno[1,2-b]pyrrol-1-yl)-ethyl]-acetamide was obtained as a yellowish solid.