2-(p-Isobutylphenyl)acrylic acid-2,2,2-trifluoroethyl ester → Ibuprofen trifluoroethyl ester

反応式

[F:1][C:2]([F:20])([F:19])[CH2:3][O:4][C:5](=[O:18])[C:6]([C:8]1[CH:13]=[CH:12][C:11]([CH2:14][CH:15]([CH3:17])[CH3:16])=[CH:10][CH:9]=1)=[CH2:7].[H][H]>CO.[C].[Pd]>[F:1][C:2]([F:19])([F:20])[CH2:3][O:4][C:5](=[O:18])[CH:6]([C:8]1[CH:13]=[CH:12][C:11]([CH2:14][CH:15]([CH3:16])[CH3:17])=[CH:10][CH:9]=1)[CH3:7]

参加物

実験手順

To a mixture of 2.86 g of 2-(p-isobutylphenyl)acrylic acid-2,2,2-trifluoroethyl ester in 50 ml of methanol was added 0.25 g of palladium-carbon(10%). Hydrogenation was carried out at ordinary temperature and pressure and stopped when a theoretical amount of hydrogen was absorbed. The palladium-carbon was filtered off to give a filtrate. The filtrate was then concentrated in vacuo to yield 2.48 g of 2-(p-isobutylphenyl)propionic acid-2,2,2-trifluoroethyl ester. Mass spectrum: parent ion 288 m/e.