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Triethylamine → HCID 44288896、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 4-Quinolinecarboxylic acid | HCID 10243 | — |
| 反応物 | Bis(2-oxo-3-oxazolidinyl)phosphinic chloride | HCID 152842 | — |
| 反応物 | (2R*,4S*)-2-benzyl-1-(3,5-dichlorobenzoyl)-4-piperidinamine | HCID 53839030 | — |
| 生成物 | HCID 44288896 | HCID 44288896 | — |
反応手順
200 mg (0.550 mmol) of (2R*,4S*)-2-benzyl-1-(3,5-dichlorobenzoyl)-4-piperidinamine are reacted in analogy to Example 4a with 105 mg (0.660 mmol) of quinoline-4-carboxylic acid, 168 mg (0.661 mmol) of bis(2-oxo-3-oxazolidinyl)phosphinic chloride and 169 μl (1.21 mmol) of triethylamine. The title compound ##STR85## is obtained (278 mg, 97%) as oil. TLC:methylene chloride/methanol/cone. ammonia (700:50:1) Rf =0.45, FD-MS:M+ =517, 519; IR:3395, 1755, 1620 cm-1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05646144 |
| 出典データセット | uspto-grants-1997_07 |
| ORD ID | ord-52f036898d6f43b883ae18229963e54c |
| 出典メモ | uspto-grants-1997_07 |