関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dihydroxyacetone | HCID 670 | — |
| 反応物 | Ammonium Hydroxide | HCID 14923 | — |
| 反応物 | Ammonium Chloride | HCID 25517 | — |
| 反応物 | 5-Bromo-2-methoxy-benzamidine | HCID 10353755 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-(5-Bromo-2-methoxyphenyl)-4-hydroxymethylimidazole | HCID 10334004 | — |
反応手順
A mixture of 5-Bromo-2-methoxy-benzamidine (1.5 g), 1,3-dihydroxy-acetone dimer (1.0 g), ammonium chloride (1.3 g), tetrahydrofuran (3 mL) and concentrated aqueous ammonium hydroxide (10 mL) was heated at 90° C. for 3 h. The reaction mixture was chilled on ice and the precipitated product was collected and recrystallized from methanol to afford 2-(5-Bromo-2-methoxyphenyl)-5-hydroxymethyl-imidazole as a yellow solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05646279 |
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| 出典データセット | uspto-grants-1997_07 |
|---|
| ORD ID | ord-1723b098082c46e9985a8431c1d72bea |
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| 出典メモ | uspto-grants-1997_07 |
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