関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 5-Bromo-2-methoxybenzaldehyde | HCID 90684 | — |
| 反応物 | Hydroxyamine hydrochloride | HCID 443297 | — |
| 反応物 | Sodium Formate | HCID 2723810 | — |
| 溶媒 | Formic Acid | HCID 284 | — |
| 生成物 | 5-Bromo-2-methoxybenzonitrile | HCID 4418560 | — |
反応手順
A mixture of 6.45 g 5-bromo-o-anisaldehyde, 2.2 g of hydroxylamine hydrochloride, 4.1 g of sodium formate and 20 mL formic acid were heated at 100° C. with stirring for 1 h. The reaction mixture was poured onto ice water and the mixture was made basic by the careful addition of 50% sodium hydroxide. The product was extracted with ether, the ether extracts were dried over magnesium sulfate and the solvent was removed in vacuo. The residue was crystallized from ether/hexane to afford 5-bromo-2-methoxybenzonitrile.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US05646281 |
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| 出典データセット | uspto-grants-1997_07 |
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| ORD ID | ord-c518a896f52f4dd3a56617238dbfa418 |
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| 出典メモ | uspto-grants-1997_07 |
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