Hydrochloric Acid → 4-Methylbenzene-1-carboximidamide hydrochloride
反応式
[C:1]1([CH3:9])[CH:6]=[CH:5][C:4]([C:7]#[N:8])=[CH:3][CH:2]=1.C[Si]([N-:14][Si](C)(C)C)(C)C.[Li+].[ClH:20]>C(OCC)C>[ClH:20].[CH3:9][C:1]1[CH:6]=[CH:5][C:4]([C:7]([NH2:14])=[NH:8])=[CH:3][CH:2]=1参加物
5
実験手順
To a solution of 12.4 g p-tolunitrile in 500 mL of diethyl ether was added 23 g of solid lithium bis(trimethylsilyl)amide at ambient temperature. The mixture was stirred for 2 hours then hydrolysed with 10% HCl at 0° C. The mixture was stirred for an additional 30 minutes and then concentrated to dryness to yield 6 g of 4-methylbenzamidine hydrochloride which was used in the next step without further purification
後処理
- stirringThe mixture was stirred for an additional 30 minutes
- concentrationconcentrated to dryness
出典と根拠
- ORDレコード
- ord-04948d1ce4804c4f88f2d37ab60e9149
- 出典データセット
- uspto-grants-1997_07
- 特許番号
- US05646281
反応ノート
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