関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethyl Acrylate | HCID 8821 | — |
| 反応物 | Potassium Acetate | HCID 517044 | — |
| 反応物 | 3-Benzyloxy-6-hydroxymethyl-2-iodopyridine | HCID 19692712 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Ethyl (3-benzyloxy-6-hydroxymethylpyridin-2-yl)propenoate | HCID 86751041 | 62% |
反応手順
To a solution of 3-benzyloxy-6-hydroxymethyl-2-iodopyridine (1.20 g, 3.50 mmol) in DMF (6.4 ml) and water (0.32 ml) were added potassium acetate (0.83 g, 8.5 mmol) palladium acetate (32 mg, 0.14 mmol) and ethyl acrylate (1.1ml, 1.01 g, 10 mmol). The mixture was placed under nitrogen and stirred and heated at 120° C. for 1.25 h. By hplc the solution yield was 62%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05646286 |
|---|
| 出典データセット | uspto-grants-1997_07 |
|---|
| ORD ID | ord-3b9686b7cdd04c39bcff3ecc3658d90a |
|---|
| 出典メモ | uspto-grants-1997_07 |
|---|
