化工社化工社 化学情報印刷レポート · 研究参考用
Ammonia → 2-Methoxyphenyl-4-methylcyclohexanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | 4-Methylcyclohexanone | HCID 11525 | — |
| 反応物 | 2-Chloroanisole | HCID 13011 | — |
| 反応物 | Sodium amide | HCID 24533 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-Methoxyphenyl-4-methylcyclohexanone | HCID 21323286 | — |
反応手順
4-Methylcyclohexanone (224 g, 2 moles) was added dropwise rapidly to a cooled, stirred suspension of 170 g (4 moles) of sodium amide in 2 l of tetrahydrofuran under nitrogen. After the addition was complete, the ice bath was removed and the mixture was heated at reflux until the evolution of ammonia ceased (~3 hours). While still at reflux, 142.5 g (1 mole) of o-chloroanisole was added rapidly dropwise and the mixture was heated for an additional hour, until evolution of ammonia ceased.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04150135 |
| 出典データセット | uspto-grants-1979_04 |
| ORD ID | ord-fac347d6f8b34305bb034a27a9abc60b |
| 出典メモ | uspto-grants-1979_04 |