Hydrochloric Acid → 6-chloro-2,2-bis(fluoromethyl)-2H-1-benzopyran-4-carboxylic acid
反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:10][C:9]([CH2:13][F:14])([CH2:11][F:12])[CH:8]=[C:7]([C:15]([O:17]CC)=[O:16])[C:6]=2[CH:20]=1.[OH-].[K+].Cl>C(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:10][C:9]([CH2:13][F:14])([CH2:11][F:12])[CH:8]=[C:7]([C:15]([OH:17])=[O:16])[C:6]=2[CH:20]=1参加物
5
実験手順
A mixture of 0.07 g of ethyl 6-chloro-2,2-bis(fluoromethyl)-2H-1-benzopyran-4-carboxylate, 0.05 g of KOH and 3 ml of ethyl alcohol was stirred at room temperature for 1 hour. Ice water and conc. HCl was added to the reaction mixture and precipitated crystals were collected by filtration to obtain 0.05 g of 6-chloro-2,2-bis(fluoromethyl)-2H-1-benzopyran-4-carboxylic acid with a melting point of 151°-152° C.
後処理
- customprecipitated crystals
- filtrationwere collected by filtration
出典と根拠
- ORDレコード
- ord-4fa8c74421374fc5810f31e8cd97a89a
- 出典データセット
- uspto-grants-1997_07
- 特許番号
- US05646308
反応ノート
読み込み中…