Water → 2-(N-[3-chlorobenzyl]isobutyramido)-4-methyloxazole

HRID 26489

反応式

HRID 26489 の反応式
[C:1]([NH:6][C:7]1[O:8][CH:9]=[C:10]([CH3:12])[N:11]=1)(=[O:5])[CH:2]([CH3:4])[CH3:3].C(=O)([O-])[O-].[K+].[K+].[Cl:19][C:20]1[CH:21]=[C:22]([CH:25]=[CH:26][CH:27]=1)[CH2:23]Br.O>CN(C)C=O>[Cl:19][C:20]1[CH:21]=[C:22]([CH:25]=[CH:26][CH:27]=1)[CH2:23][N:6]([C:7]1[O:8][CH:9]=[C:10]([CH3:12])[N:11]=1)[C:1](=[O:5])[CH:2]([CH3:4])[CH3:3]

参加物

6

反応物 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 698381-(Bromomethyl)-3-chlorobenzeneHCID 233485622-iso Butyramido-4-methyloxazole

生成物 1

HCID 213236682-(N-[3-chlorobenzyl]isobutyramido)-4-methyloxazole

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
70 °C

実験手順

2-iso Butyramido-4-methyloxazole (11.1 g., 0.066 mol) prepared in a manner similar to that described in Example 20, was dissolved in dry dimethylformamide. Solid potassium carbonate (10.47 g., 0.076 mol) and 3-chlorobenzyl bromide (15.6 g., 0.076 mol) were added and the stirred mixture was heated at 70° C. for 2 hours, cooled and poured into cold water. The solution was extracted with ether and the extract was dried over magnesium sulphate and evaporated. The residue was distilled to give the product, 12.3 g., b.p. 115-120° C./0.08 mm.

後処理

  1. temperaturecooled
  2. extractionThe solution was extracted with ether
  3. dry with materialthe extract was dried over magnesium sulphate
  4. customevaporated
  5. distillationThe residue was distilled
  6. customto give the product, 12.3 g

出典と根拠

ORDレコード
ord-67daa2cca30b41ff8b2d549f760e35e1
出典データセット
uspto-grants-1979_04
特許番号
US04150143

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