化工社化工社 化学情報印刷レポート · 研究参考用
1-Indanone → 2,3-Dihydro-N-benzyl-1H-inden-1-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Indanone | HCID 6735 | — |
| 反応物 | Benzylamine | HCID 7504 | — |
| 反応物 | Ethyl bromoacetate | HCID 7748 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 生成物 | 2,3-Dihydro-N-benzyl-1H-inden-1-amine | HCID 10130724 | — |
反応手順
The amino acid was synthesized as described by Miyake, et al., Takeda Kenkyushoho 44: 171-185 (1985). [Chem. Abstr. 106: 156830 (1987)]. N-(1-indanyl)-benzylamine was prepared by reductive amination of 1-indanone with benzylamine, and alkylation of the amine by ethyl bromoacetate. The benzyl group was cleaved by hydrogenolysis over palladium. Saponification of the ethyl ester gave the amino acid, which was converted to the Boc derivative by the standard procedure described in Example III.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05648336 |
| 出典データセット | uspto-grants-1997_07 |
| ORD ID | ord-7f2f1b591a2445f18913943b894b5a90 |
| 出典メモ | uspto-grants-1997_07 |