Sodium Bicarbonate → 4-Hydroxy-7-[2-[[3-[[2-(2-phenylethoxy)ethyl]sulfonyl]propyl]amino]ethyl]-2(3H)-benzothiazolone
反応式
Cl.[OH:2][C:3]1[C:8]2[NH:9][C:10](=[O:12])[S:11][C:7]=2[C:6]([CH2:13][CH2:14][NH:15][CH2:16][CH2:17][CH2:18][S:19]([CH2:22][CH2:23][O:24][CH2:25][CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)(=[O:21])=[O:20])=[CH:5][CH:4]=1.C(=O)([O-])O.[Na+]>>[OH:2][C:3]1[C:8]2[NH:9][C:10](=[O:12])[S:11][C:7]=2[C:6]([CH2:13][CH2:14][NH:15][CH2:16][CH2:17][CH2:18][S:19]([CH2:22][CH2:23][O:24][CH2:25][CH2:26][C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)(=[O:21])=[O:20])=[CH:5][CH:4]=1参加物
3
実験手順
An aqueous solution (500 ml) of the title compound from Example 20 (4.9 g) was mixed with an excess of aqueous sodium hydrogen carbonate. The free base was extracted with chloroform and the combined extracts were washed with water and dried (MgSO4), filtered and the chloroform removed under reduced pressure to yield the subtitled compound as an off-white solid (4.22 g, 91%).
後処理
- extractionThe free base was extracted with chloroform
- washthe combined extracts were washed with water
- dry with material