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Methyl Ethyl Ketone → 1,4,5-Triphenyl-3-(7-bromoheptyl)imidazol-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl Ethyl Ketone | HCID 6569 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1,4,5-Triphenyl-1,3-dihydro-2H-imidazol-2-one | HCID 628544 | — |
| 反応物 | 4,4-Dibromoheptane | HCID 21679102 | — |
| 生成物 | 1,4,5-Triphenyl-3-(7-bromoheptyl)imidazol-2-one | HCID 22916388 | 46% |
反応手順
A mixture of 1,4,5-triphenylimidazol-2-one (15.3 g), dibromoheptane (50.6 g) and potassium carbonate (13.8 g) was heated at reflux temperature in dry butanone (750 ml) for 20 hours. The mixture was cooled, filtered and the filtrate evaporated to an oil which was chromatographed on silica gel (hexane/ethyl acetate) to give 1,4,5-triphenyl-3-(7-bromoheptyl)imidazole-2-one (11.1 g, 46%) as an oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05648373 |
| 出典データセット | uspto-grants-1997_07 |
| ORD ID | ord-37c6d3059e04483fafa6f3e031bbe891 |
| 出典メモ | uspto-grants-1997_07 |