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2,4,5-Triphenylimidazole → 1-(7-Bromoheptyl)-2,4,5-triphenylimidazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,4,5-Triphenylimidazole | HCID 10232 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1,7-Dibromoheptane | HCID 78309 | — |
| 溶媒 | Methyl Ethyl Ketone | HCID 6569 | — |
| 生成物 | 1-(7-Bromoheptyl)-2,4,5-triphenylimidazole | HCID 22916377 | 61.5% |
反応手順
A mixture of 2,4,5-triphenylimidazole (11.5 g), 1,7-dibromo-heptane (50 g) and potassium carbonate (27 g) in dry butanone (250 ml) was heated at reflux for 20 hours. The mixture was filtered and the filtrate evaporated to an oil. Chromatography on silica gel (hexane/ethyl acetate) and recrystallisation from hexane gave 1-(7-bromoheptyl)-2,4,5-triphenylimidazole (11.3 g, 61.4%) as a colourless solid, m.p. 69°-71°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05648373 |
| 出典データセット | uspto-grants-1997_07 |
| ORD ID | ord-20d0f6ec73f5498fbde81cc099d2687a |
| 出典メモ | uspto-grants-1997_07 |