2,4,5-Triphenylimidazole → 1-(7-Bromoheptyl)-2,4,5-triphenylimidazole

HRID 265366

反応式

HRID 265366 の反応式
[C:1]1([C:7]2[NH:8][C:9]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31]Br.C(=O)([O-])[O-].[K+].[K+]>CC(=O)CC>[Br:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][N:11]1[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[C:9]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[N:8]=[C:7]1[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

5

反応物 3

HCID 102322,4,5-TriphenylimidazoleHCID 11430Potassium CarbonateHCID 783091,7-Dibromoheptane

生成物 1

HCID 229163771-(7-Bromoheptyl)-2,4,5-triphenylimidazole収率 61.5%

試薬・触媒・溶媒 1

HCID 6569Methyl Ethyl Ketone溶媒

実験手順

A mixture of 2,4,5-triphenylimidazole (11.5 g), 1,7-dibromo-heptane (50 g) and potassium carbonate (27 g) in dry butanone (250 ml) was heated at reflux for 20 hours. The mixture was filtered and the filtrate evaporated to an oil. Chromatography on silica gel (hexane/ethyl acetate) and recrystallisation from hexane gave 1-(7-bromoheptyl)-2,4,5-triphenylimidazole (11.3 g, 61.4%) as a colourless solid, m.p. 69°-71°.

後処理

  1. temperaturewas heated
  2. temperatureat reflux for 20 hours
  3. filtrationThe mixture was filtered
  4. customthe filtrate evaporated to an oil
  5. customChromatography on silica gel (hexane/ethyl acetate) and recrystallisation from hexane

出典と根拠

ORDレコード
ord-20d0f6ec73f5498fbde81cc099d2687a
出典データセット
uspto-grants-1997_07
特許番号
US05648373

関連ノート

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