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Hydrogen Bromide → 2-Bromo-1-(1-naphthalenyl)ethanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrogen Bromide | HCID 260 | — |
| 反応物 | Chloroform | HCID 6212 | — |
| 反応物 | 1-Acetylnaphthalene | HCID 13663 | — |
| 触媒 | Copper bromide (CuBr2) | HCID 24611 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 2-Bromo-1-(1-naphthalenyl)ethanone | HCID 3830513 | — |
反応手順
Methyl 1-naphthyl ketone (10.1 g.), in 50 ml of a 1:1 mixture of chloroform and ethyl acetate is treated with 26.5 g. of copper (II) bromide. The resulting reaction mixture is heated under reflux with vigorous stirring until the evolution of hydrogen bromide ceases. When the reaction is complete the solvent is removed, ether is added and the copper (I) bromide is removed by filtration. Evaporation of the filtrate under reduced pressure yields crude bromomethyl 1-naphthyl ketone.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04150153 |
| 出典データセット | uspto-grants-1979_04 |
| ORD ID | ord-1489e7152d2f4faab50106df544efc62 |
| 出典メモ | uspto-grants-1979_04 |