Methylparaben → Methyl 4-(4-bromobutoxy)benzoate
反応式
[Br:1][CH2:2][CH2:3][CH2:4][CH2:5]Br.[OH:7][C:8]1[CH:17]=[CH:16][C:11]([C:12]([O:14][CH3:15])=[O:13])=[CH:10][CH:9]=1.C(=O)([O-])[O-].[K+].[K+]>CC(=O)CC>[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][O:7][C:8]1[CH:9]=[CH:10][C:11]([C:12]([O:14][CH3:15])=[O:13])=[CH:16][CH:17]=1参加物
5
実験手順
A mixture of 1,4 dibromobutane (50 ml), methyl 4-hydroxy-benzoate (15.2 g, 0.1 mole), potassium carbonate (40 g) in 2-butanone (500 ml) was refluxed for 24 hours. The mixture was filtered, solvent removed and the residue was chromatographed on silica gel eluted with chloroform/petrol and recrystallised from pentane to give methyl 4-(4-bromobutyloxy)benzoate (19.26 g).
後処理
- temperaturewas refluxed for 24 hours
- filtrationThe mixture was filtered
- customsolvent removed
- customthe residue was chromatographed on silica gel
- washeluted with chloroform/petrol
- customrecrystallised from pentane
出典と根拠
- ORDレコード
- ord-70044cf59d9d4b0d84034916305dc678
- 出典データセット
- uspto-grants-1997_07
- 特許番号
- US05648373
反応ノート
読み込み中…