Phosphoric Acid → Diacetylguanine

HRID 265619

反応式

HRID 265619 の反応式
C(O[C:5](=[O:7])[CH3:6])(=O)C.[NH:8]1[C:17](=[O:18])[C:16]2[NH:15][CH:14]=[N:13][C:12]=2[N:11]=[C:9]1[NH2:10].P(=O)(O)(O)O.[CH3:24][C:25](OC(C)=O)=[O:26].CC(O)=O.N1C(=O)C2NC=NC=2N=C1N.OP(O)(O)=O>C(O)(=O)C>[C:25]([N:10]([C:5](=[O:7])[CH3:6])[C:9]1[NH:8][C:17](=[O:18])[C:16]2[NH:15][CH:14]=[N:13][C:12]=2[N:11]=1)(=[O:26])[CH3:24]

参加物

6

反応物 4

HCID 1004Phosphoric AcidHCID 7918Acetic AnhydrideHCID 135398634Guanine2 回HCID 136333567Ac2O AcOH guanine H3PO4

生成物 1

HCID 136360183Diacetylguanine収率 94%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

The effect of the ratio of acetic anhydride and acetic acid on the reaction time and yield was also studied. In general, any range of acetic anhydride, acetic acid, guanine and phosphoric acid can be used that provides the desired results. In the present work, it was found that a ratio of 15/10/1/0.05 (ml) of Ac2O/AcOH/guanine/H3PO4 is preferred. It was discovered that guanine could be acetylated using this ratio of reactants at reflux for 15 hours to give diacetylguanine with minimal discoloration in approximately 94% yield.

後処理

  1. customthat provides the
  2. customdesired results
  3. temperatureat reflux for 15 hours

出典と根拠

ORDレコード
ord-2dd00a3383ab4807a8e70bcba85977bd
出典データセット
uspto-grants-1997_07
特許番号
US05648489

関連ノート

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