Pivalaldehyde → 3-[(2,2-Dimethylpropylideneamino)-methyl]-pyrrolidine

HRID 265701

反応式

HRID 265701 の反応式
[NH2:1][CH2:2][CH:3]1[CH2:7][CH2:6][NH:5][CH2:4]1.[CH:8](=O)[C:9]([CH3:12])([CH3:11])[CH3:10]>CO>[CH3:8][C:9]([CH3:12])([CH3:11])[CH:10]=[N:1][CH2:2][CH:3]1[CH2:7][CH2:6][NH:5][CH2:4]1

参加物

4

反応物 2

HCID 12417PivalaldehydeHCID 50687753-Pyrrolidinemethanamine

生成物 1

HCID 148366083-[(2,2-Dimethylpropylideneamino)-methyl]-pyrrolidine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

2.0 g (20 mmol) of 3-aminomethyl-pyrrolidine are initially introduced into 10 ml of methanol, and 1.8 g (22 mmol) of 97% strength pivalaldehyde are added dropwise at room temperature, after which the internal temperature rises to 30° C. The mixture is subsequently stirred for 1 hour and then concentrated, and the residue is distilled through a Vigreux column.

後処理

  1. additionare added dropwise at room temperature
  2. customrises to 30° C
  3. concentrationconcentrated
  4. distillationthe residue is distilled through a Vigreux column

出典と根拠

ORDレコード
ord-9c01c9fb7d9f417293a6327e6e7f8468
出典データセット
uspto-grants-1997_07
特許番号
US05648493

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