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Methyl Isocyanate → N-(3-methyl-5-isothiazolyl)-N'-methylurea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl Isocyanate | HCID 12228 | — |
| 反応物 | 3-Methylisothiazol-5-amine | HCID 32307 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | N-(3-methyl-5-isothiazolyl)-N'-methylurea | HCID 23336007 | 54.5% |
反応手順
Methylisocyanate (1.96 milliliters, 0.04 mole) was added dropwise to a thirty (30) milliliter solution of tetrahydrofuran (distilled from calcium hydride) containing the above mentioned 5-amino-3-methylisothiazole (5.0 grams, 0.04 mole), and then the resulting yellow solution was refluxed for 3 hours, during which time a white precipitate formed. The solution was cooled and filtered, giving 3.73 grams of 1-(3-methyl-5-isothiazolyl)-3-methylurea, also referred to as 3-methyl-5-N-methylureidoisothiazole.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04150226 |
| 出典データセット | uspto-grants-1979_04 |
| ORD ID | ord-4dabd8acaf6f44008abf1131372dba24 |
| 出典メモ | uspto-grants-1979_04 |