Sulfuric Acid → 6-Bromo-1,1-dimethyl-1,2,3,4-tetrahydronaphthalene

HRID 265762

反応式

HRID 265762 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][CH2:10][C:11]([CH3:14])(O)[CH3:12])[CH:5]=[CH:6][CH:7]=1.OS(O)(=O)=O>O>[Br:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:6][CH:7]=1)[C:11]([CH3:14])([CH3:12])[CH2:10][CH2:9][CH2:8]2

参加物

4

反応物 2

HCID 1118Sulfuric AcidHCID 225715955-(3-Bromophenyl)-2-methylpentan-2-ol2 回

生成物 1

HCID 105860636-Bromo-1,1-dimethyl-1,2,3,4-tetrahydronaphthalene

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

15.0 g (58.3 mmol) of 5-(3-bromophenyl)-2-methylpentan-2-ol (Compound E) was cooled to 0° C. and then 2.8 ml of conc. H2SO4 was added. The mixture was stirred for 2.5 hours, diluted with water (20 ml) and extracted with Et2O (3×40 ml). The combined organic layers were washed with water, sat. aqueous NaHCO3 and brine, dried over MgSO4 and concentrated in vacuo. Purification by Kugelrohr distillation gave the title compound as a colorless oil.

後処理

  1. extractionextracted with Et2O (3×40 ml)
  2. washThe combined organic layers were washed with water, sat. aqueous NaHCO3 and brine
  3. dry with materialdried over MgSO4
  4. concentrationconcentrated in vacuo
  5. customPurification
  6. distillationby Kugelrohr distillation

出典と根拠

ORDレコード
ord-52c3b975a4ff4d7081c1963b6454b7db
出典データセット
uspto-grants-1997_07
特許番号
US05648514

関連ノート

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