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3-Methoxyacetophenone → 2-Chlorohydrocinnamonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Methoxyacetophenone | HCID 11460 | — |
| 反応物 | 3-(2-Chlorophenyl)propan-1-amine | HCID 5200411 | — |
| 生成物 | 2-Chlorohydrocinnamonitrile | HCID 580668 | — |
| 生成物 | 3-(2-Chlorophenyl)propan-1-amine | HCID 5200411 | — |
反応手順
The imine V was prepared in a manner similar to that of imine III in Example I using 3-(2-chlorophenyl)propylamine and 3'-methoxyacetophenone. 3-(2-chlorophenyl)propylamine was obtained by the reduction (BH3 --SMe2 complex) of 2-chlorohydrocinnamonitrile (Aldrich Chemical Co., Milwaukee, Wis., U.S.A.). This process afforded 1-methyl-1-(3-methoxy)phenyl-5-(2-chloro)phenyl-2-aza-1-pentene (imine V), a single component, as analyzed by GC/EI-MS: m/z (rel. int.) 301 (M+, 1), 266 (22), 162 (100), 125 (26), 91 (13), 77 (9).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05648541 |
| 出典データセット | uspto-grants-1997_07 |
| ORD ID | ord-ccec9dc553444c4cad874fd7dc57aedd |
| 出典メモ | uspto-grants-1997_07 |