Lithium hydroxide, monohydrate → 4'-Cyano[1,1'-biphenyl]-4-carboxylic acid
反応式
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([O:17]C)=[O:16])=[CH:11][CH:10]=2)=[CH:5][CH:4]=1)#[N:2].O[Li].O>C1COCC1.CO.O.CCOC(C)=O>[C:1]([C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([OH:17])=[O:16])=[CH:11][CH:10]=2)=[CH:7][CH:8]=1)#[N:2]参加物
5
実験手順
Compound 18-3 (3.4 g, 15.1 mmole), and LiOH·H2O (3.1 g, 75.5 mmol) were dissolved in THF/MeOH/H2O (30 mL/30 mL/30 mL) and stirred at room temperature overnight. The solution was diluted with EtOAc and washed with 10% KHSO4. The organic layer was washed with brine, dried over MgSO4, filtered and concentrated to yield 18-4 as a white solid.
後処理
- washwashed with 10% KHSO4
- washThe organic layer was washed with brine
- dry with materialdried over MgSO4
- filtrationfiltered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-adc7046b4d5547e6b0398afc88023ffc
- 出典データセット
- uspto-grants-1997_07
- 特許番号
- US05648368
反応ノート
読み込み中…