関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetic Anhydride | HCID 7918 | — |
| 反応物 | 1-Bromopentane | HCID 8057 | — |
| 反応物 | 2-Pentanone, 5-chloro- | HCID 79993 | — |
| 反応物 | Magnesium | HCID 5462224 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 1-Chloro-4-acetoxy-4-methylnonane | HCID 20386091 | — |
反応手順
To the Grignard reagent prepared from 1-bromopentane (4.8 g., 0.04 mole) and magnesium (0.96 g., 0.04 mole) in ether is added 5-chloro-2-pentanone (6.0 g., 0.04 mole). The reaction mixture is stirred at 25° C. for 1 hour and then cooled to 15° C. Acetic anhydride (6 ml., excess) is added carefully and the solution is allowed to stand for 20 hours. Water is added, and the ether layer is separated, washed with brine, and dried over sodium sulfate. Distillation affords the title compound in 4.3 g. (46%) yield, b.p. 88° C. (0.1 mm.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04150235 |
|---|
| 出典データセット | uspto-grants-1979_04 |
|---|
| ORD ID | ord-128778f48ccd4e9884777d39704485c0 |
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| 出典メモ | uspto-grants-1979_04 |
|---|
