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Diethyl Ether → N,N-Bis(2-chloroethyl)benzylamine hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diethyl Ether | HCID 3283 | — |
| 反応物 | Chloroform | HCID 6212 | — |
| 反応物 | 2,2'-((Phenylmethyl)imino)bisethanol | HCID 7553 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 生成物 | N,N-Bis(2-chloroethyl)benzylamine hydrochloride | HCID 2777881 | — |
反応手順
Thionyl chloride (25.4 g, 130 mmol) and chloroform (20 mL) are combined. A solution of N,N-bis(2-hydroxyethyl)-N-benzylamine (25.4 g, 130 mmol) in chloroform (20 mL) is added dropwise over 1 hour. When the addition is complete the reaction mixture is refluxed for 1 hour. The reaction mixture is cooled to ambient temperature and diethyl ether was added to form a solid which is collected by filtration, rinsed with diethyl ether, and dried to give the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05648366 |
| 出典データセット | uspto-grants-1997_07 |
| ORD ID | ord-296764c90a7140689aa64d02bd1858d6 |
| 出典メモ | uspto-grants-1997_07 |