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Trifluoroacetic acid → [2-(4-Chlorobenzothiazolyl)][1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]methanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1-(2-Bromoethyl)-4-methoxybenzene | HCID 84427 | — |
| 反応物 | [2-(4-Chlorobenzothiazolyl)](4-piperidinyl)methanone | HCID 53815766 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | [2-(4-Chlorobenzothiazolyl)][1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]methanone | HCID 54412977 | — |
反応手順
Mix [2-(4-chlorobenzothiazolyl)](4-piperidinyl)methanone.CF3CO2H (9.19 mmol), 2-(4-methoxyphenyl)ethyl bromide (2.07 g, 9.64 mmol), potassium carbonate (3.33 g, 24.1 mmol) and dimethylformamide (35 mL) and heat at 90° C. overnight. Cool to room temperature and partition between a 2:1 mixture of ethyl acetate/toluene and water. Separate the aqueous phase and wash the organic phase with water and brine. Dry (MgSO4) and evaporate the solvent in vacuo. Purify by chromatography to give the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05650416 |
| 出典データセット | uspto-grants-1997_07 |
| ORD ID | ord-8ac0bccc17544f73a370f0721b0c23b8 |
| 出典メモ | uspto-grants-1997_07 |