Diethylamine → benzyl 4-(N,N-diethylamino)butanoate
反応式
Br[CH2:2][CH2:3][CH2:4][C:5]([O:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:6].[CH2:15]([NH:17][CH2:18][CH3:19])[CH3:16]>ClCCl>[CH2:15]([N:17]([CH2:2][CH2:3][CH2:4][C:5]([O:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:6])[CH2:18][CH3:19])[CH3:16]参加物
4
実験手順
A mixture of benzyl 4-bromobutanoate (58.6 diethylamine (58.3 g) and dichloromethane (1000 ml) was stirred under reflux for 14 hours. The reaction mixture was washed with water and dried over magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was subjected to column chromatography on silica gel. The fractions eluted with ethyl acetate gave benzyl 4-(N,N-diethylamino)butanoate (33.8 g, 60%).
後処理
- temperatureunder reflux for 14 hours
- washThe reaction mixture was washed with water
- dry with materialdried over magnesium sulfate
- customthe solvent was evaporated under reduced pressure
- washThe fractions eluted with ethyl acetate
出典と根拠
- ORDレコード
- ord-5a0cea2b15534838b31d8da8b7eb66e2
- 出典データセット
- uspto-grants-1997_07
- 特許番号
- US05650410
反応ノート
読み込み中…