化工社化工社 化学情報印刷レポート · 研究参考用
HRID 266245作成日：2026年10月26日
Diisopropyl Ether → (2Z)-2-[2-(dimethylaminomethylideneamino)-1,3-thiazol-4-yl]-2-methoxyiminoacetyl chloride;hydrochloride
https://huagongshe.com/reaction/266245
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Diisopropyl Ether | HCID 7914 | — |
| 反応物 | (alphaZ)-2-Amino-alpha-(methoxyimino)-4-thiazoleacetic acid | HCID 5486924 | — |
| 反応物 | Dimethylaminochloromethyleneammonium chloride | HCID 86750850 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | (2Z)-2-[2-(dimethylaminomethylideneamino)-1,3-thiazol-4-yl]-2-methoxyiminoacetyl chloride;hydrochloride | HCID 140382097 | 96.9% |
反応手順
Dimethylaminochloromethyleneammonium chloride (1.54 g, 12.0 mmol) was dissolved in 7 ml of tetrahydrofuran, followed by cooling to -12° C. Added to the solution were 1.10 g (5.5 mmol) of (Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetic acid and the resulting mixture was stirred for 40 minutes. Isopropyl ether (16 ml) was added to the reaction mixture, followed by stirring for 40 minutes. Deposited crystals were collected under a nitrogen gas stream, collected by filtration and then dried, whereby 1.65 g of the title compound were obtained (yield: 96.9%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05650518 |
|---|
| 出典データセット | uspto-grants-1997_07 |
|---|
| ORD ID | ord-a2d5756d3e9f45d38aee089027d73d8e |
|---|
| 出典メモ | uspto-grants-1997_07 |
|---|
