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HRID 266270作成日：2026年10月25日

3,4-dihydro-2H-pyran → (RS)-2-(4-chlorobenzenesulfonylamino)-N-(3-(methoxycarbonylmethyl)phenyl)-3-(tetrahydropyran-2-yloxy)propanamide

https://huagongshe.com/reaction/266270

反応式

関与物質

役割名称HCID仕込み量
反応物3,4-dihydro-2H-pyranHCID 8080—
反応物2-(4-Chlorobenzenesulfonamido)-3-hydroxypropanoic acidHCID 4229170—
反応物Methyl 3-aminophenylacetateHCID 13054266—
生成物(RS)-2-(4-chlorobenzenesulfonylamino)-N-(3-(methoxycarbonylmethyl)phenyl)-3-(tetrahydropyran-2-yloxy)propanamideHCID 19032843—

反応手順

The procedure described in Example 1 was repeated, except that dihydropyran (0.4 ml) and methyl m-aminophenylacetate (604 mg) were successively reacted with (RS)-2-(4-chlorobenzenesulfonylamino)-3-hydroxypropanoic acid (893 mg) to obtain (RS)-2-(4-chlorobenzenesulfonylamino)-N-(3-(methoxycarbonylmethyl)phenyl)-3-(tetrahydropyran-2-yloxy)propanamide (624 mg).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US05650428
出典データセットuspto-grants-1997_07
ORD IDord-f84d84434c3f469d88f59693f6b2d043
出典メモuspto-grants-1997_07