化工社化工社 化学情報印刷レポート · 研究参考用
4-Iodobenzenesulfonyl chloride → 3-(Tetrahydropyran-2-yloxy)propanamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Iodobenzenesulfonyl chloride | HCID 7399 | — |
| 反応物 | (RS)-2-(benzyloxycarbonylamino)-N-(4-(ethoxycarbonylmethyl)phenyl)-3-(tetrahydropyran-2-yloxy)propanamide | HCID 19032873 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 生成物 | 3-(Tetrahydropyran-2-yloxy)propanamide | HCID 20393361 | 307.7% |
反応手順
The procedure described in Example 15 was repeated, except that (RS)-2-(benzyloxycarbonylamino)-N-(4-(ethoxycarbonylmethyl)phenyl)-3-(tetrahydropyran-2-yloxy)propanamide (1.0 g) was hydrogenolyzed in the presence of 10% Pd-C, and then, reacted with 4-iodobenzenesulfonyl chloride (1.31 g) to obtain (RS)-N-(4-(ethoxycarbonyl-methyl)phenyl)-2-(4-iodobenzenesulfonylamino)-N-(3-(tetrahydropyran-2-yloxy)propanamide (1.10 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05650428 |
| 出典データセット | uspto-grants-1997_07 |
| ORD ID | ord-17675e42e92f48978a6ebe92b16e83d1 |
| 出典メモ | uspto-grants-1997_07 |