Hydrochloric Acid → 1-Methyl-3-phenyl-5-(2-hydroxymethylphenyl)-1,2,4-triazole
反応式
[CH:1](=[N:8][N:9]([C:11]1[C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=2[CH2:14][O:13][N:12]=1)[CH3:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl>C(O)C>[OH:13][CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[C:11]1[N:9]([CH3:10])[N:8]=[C:1]([C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[N:12]=1参加物
4
反応条件
- 温度
- 0 °C
実験手順
A suspension of 1.2 g. of 4-(2-benzylidene-1-methylhydrazino)-1H-2,3-benzoxazine in 12 ml. of ethanol and 12 ml. of aqueous 5% HCl is heated on a water bath for three hours. The ethanol is removed by distillation and the residue, neutralized with aqueous NaHCO3, is cooled to about 0° C. The precipitate is filtered and crystallized from ethanol. M.p. 122° C. Yield 96%.