Methyl Ethyl Ketone → HCID 70051691、化合物

HRID 266462ノート

反応式

HRID 266462 の反応式
[CH2:1]([N:8]1[C:18](=[O:19])[C:17]2[C:12](=[CH:13][C:14]([OH:20])=[CH:15][CH:16]=2)[S:9]1(=[O:11])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:21][O:22][CH2:23][CH2:24][O:25][CH2:26][CH2:27]Br.C(=O)([O-])[O-].[K+].[K+].C(C(C)=O)C>CN(C)C=O>[CH2:1]([N:8]1[C:18](=[O:19])[C:17]2[C:12](=[CH:13][C:14]([O:20][CH2:27][CH2:26][O:25][CH2:24][CH2:23][O:22][CH3:21])=[CH:15][CH:16]=2)[S:9]1(=[O:11])=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

6

反応物 4

HCID 6569Methyl Ethyl KetoneHCID 11430Potassium CarbonateHCID 1235321-Bromo-3,6-dioxaheptaneHCID 70053010HCID 70053010、化合物

生成物 1

HCID 70051691HCID 70051691、化合物収率 78%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A mixture of 2-benzyl-6-hydroxysaccharin (0.86 g), 2-bromoethyl 2-methoxyethyl ether (d=1.347, 0.45 mL), potassium carbonate (1.24 g), methyl ethyl ketone (50 mL) and dimethylformamide (2 mL) was heated under reflux for five hours, then poured into ice-water (500 mL). The resulting solid was collected, washed with water and dried affording 2-benzyl-6-[2-(2-methoxyethoxy)ethoxy]saccharin (0.92 g, 78% yield, mp 86°-88° C.).

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for five hours
  3. customThe resulting solid was collected
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-733dbf6e7af74257b4b4a47719fb9b29
出典データセット
uspto-grants-1997_07
特許番号
US05650422

反応ノート

読み込み中…