関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Ethanethiol | HCID 6343 | — |
| 反応物 | Aluminum(III) Chloride | HCID 6451240 | — |
| 反応物 | 4-Isopropyl-6-methoxysaccharin | HCID 10147362 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 4-Isopropyl-6-hydroxysaccharin | HCID 10037346 | 97% |
反応手順
Ethanethiol (43.9 g) was added with stirring to a suspension of aluminum chloride (62.74 g) in chloroform (500 mL) at 0° C. To the resulting solution was added a solution of 4-isopropyl-6-methoxysaccharin (20.0 g) in chloroform (550 mL) during 30 minutes. The resulting solution was warmed to and maintained at 60° C. for 3-4 hours, then poured into ice-water acidified with hydrochloric acid. The resulting solid was collected by filtration, washed with water and dried affording 4-isopropyl-6-hydroxysaccharin, 18.4 g., 97% yield.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05650422 |
|---|
| 出典データセット | uspto-grants-1997_07 |
|---|
| ORD ID | ord-306bf5c300b14710a29032a6cc846099 |
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| 出典メモ | uspto-grants-1997_07 |
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