Sulfuryl chloride → 2-Chloromethyl-4-ethoxy-6-propyl-7-methoxysaccharin
反応式
C1(S[CH2:8][N:9]2[C:19](=[O:20])[C:18]3[C:13](=[C:14]([O:27][CH3:28])[C:15]([CH2:24][CH2:25][CH3:26])=[CH:16][C:17]=3[O:21][CH2:22][CH3:23])[S:10]2(=[O:12])=[O:11])C=CC=CC=1.S(Cl)([Cl:32])(=O)=O>ClCCl>[Cl:32][CH2:8][N:9]1[C:19](=[O:20])[C:18]2[C:13](=[C:14]([O:27][CH3:28])[C:15]([CH2:24][CH2:25][CH3:26])=[CH:16][C:17]=2[O:21][CH2:22][CH3:23])[S:10]1(=[O:12])=[O:11]参加物
4
実験手順
By the method of part E of Example 45 2-phenylthiomethyl-4-ethoxy-6-propyl-7-methoxysaccharin (0.85 g) was reacted with sulfuryl chloride (0.30 g) in dichloromethane and purified with hexane affording 2-chloromethyl-4-ethoxy-6-propyl-7-methoxysaccharin, 0.62 g, 89% yield, mp 131°-133° C.