Triethyl 2-phosphonopropionate → 2-Phosphonopropionic acid

HRID 26655

反応式

HRID 26655 の反応式
C([O:3][C:4](=[O:15])[CH:5]([P:7]([O:12]CC)([O:9]CC)=[O:8])[CH3:6])C>Cl>[P:7]([CH:5]([CH3:6])[C:4]([OH:15])=[O:3])([OH:12])([OH:9])=[O:8]

参加物

3

反応物 1

HCID 107155Triethyl 2-phosphonopropionate

生成物 1

HCID 731872-Phosphonopropionic acid

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

A mixture of ethyl-2-(diethoxyphosphinyl)propionate (15 g., 0.063 moles) in 6 N hydrochloric acid (150 ml.) is heated to reflux for 2.5 hours. After this time, the reaction vessel is fitted with a Dean-Stark trap and heated at reflux an additional thirty minutes. The reaction mixture is concentrated in vacuo to yield 2-phosphonopropionic acid (quantitative).

後処理

  1. temperatureis heated
  2. temperatureto reflux for 2.5 hours
  3. customAfter this time, the reaction vessel is fitted with a Dean-Stark trap
  4. temperatureheated
  5. temperatureat reflux an additional thirty minutes
  6. concentrationThe reaction mixture is concentrated in vacuo

出典と根拠

ORDレコード
ord-51634a379c774f2fb0c7ff187d1ea7c9
出典データセット
uspto-grants-1979_04
特許番号
US04151172

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