Ethyl orthoformate → HCID 54487700、化合物

HRID 266561ノート

反応式

HRID 266561 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:15])[CH2:9][C:10]([CH:12]2[CH2:14][CH2:13]2)=[O:11])=[C:4]([S:16]([CH3:19])(=[O:18])=[O:17])[CH:3]=1.[CH:20](OCC)(OCC)[O:21][CH2:22][CH3:23]>C(OC(=O)C)(=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:15])[C:9](=[CH:20][O:21][CH2:22][CH3:23])[C:10]([CH:12]2[CH2:13][CH2:14]2)=[O:11])=[C:4]([S:16]([CH3:19])(=[O:18])=[O:17])[CH:3]=1

参加物

4

反応物 2

HCID 31214Ethyl orthoformateHCID 545513651-[4-Chloro-2-(methanesulfonyl)phenyl]-3-cyclopropylpropane-1,3-dione

生成物 1

HCID 54487700HCID 54487700、化合物収率 99.7%

試薬・触媒・溶媒 1

HCID 7918Acetic Anhydride溶媒

実験手順

A mixture of 1-(4-chloro-2-methylsulphonylphenyl)-3-cyclopropylpropan-1,3-dione (7.1 g) and triethyl orthoformate (6.9 g) in acetic anhydride was stirred and heated at reflux for 2 hours. The mixture was evaporated to dryness, toluene was added and the solution was re-evaporated to give 1-(4-chloro-2-methylsulphonylphenyl)-3-cyclopropyl-2-ethoxymethylenepropan-1,3-dione (8.4 g) as a red gum which was not purified further.

後処理

  1. temperatureheated
  2. temperatureat reflux for 2 hours
  3. customThe mixture was evaporated to dryness, toluene
  4. additionwas added
  5. customthe solution was re-evaporated

出典と根拠

ORDレコード
ord-4ad750e0c8084a108f9b7f4827ee98a6
出典データセット
uspto-grants-1997_07
特許番号
US05650533

反応ノート

読み込み中…