Hydrochloric Acid → HCID 67703428、化合物

HRID 266641ノート

反応式

HRID 266641 の反応式
[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:21][CH3:22])=[C:6]2[C:11]=1[O:10][CH2:9][C@H:8]([N:12]([CH:16]([CH2:19][CH3:20])[CH2:17][CH3:18])[CH2:13][CH2:14][CH3:15])[CH2:7]2.[ClH:23]>CCOCC>[ClH:23].[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:21][CH3:22])=[C:6]2[C:11]=1[O:10][CH2:9][C@H:8]([N:12]([CH:16]([CH2:19][CH3:20])[CH2:17][CH3:18])[CH2:13][CH2:14][CH3:15])[CH2:7]2

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 53908906HCID 53908906、化合物

生成物 1

HCID 67703428HCID 67703428、化合物

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

(R)-8-Fluoro-5-methoxy-3-(N-3-pentyl-N-n-propylamino)chroman (4.59 g, 14.8 mmol) was dissolved in ether. HCl in ether was added to precipitate the HCl-salt, and gave after drying 4.59 g of (R)-8-fluoro-5-methoxy-3-(N-3-pentyl-N-n-propylamino)chroman hydrochloride as a white powder. Mp. 30°-50° C. (sinters).

後処理

  1. customto precipitate the HCl-salt
  2. customgave
  3. dry with materialafter drying 4.59 g of (R)-8-fluoro-5-methoxy-3-(N-3-pentyl-N-n-propylamino)chroman hydrochloride as a white powder

出典と根拠

ORDレコード
ord-04ebb12081cd4b65ac496c34a918039e
出典データセット
uspto-grants-1997_07
特許番号
US05650524

反応ノート

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