Toluene → 1,2,3,4-Tetrahydro-1,1,4,4,6-pentamethylnaphthalene

HRID 266671

反応式

HRID 266671 の反応式
Cl[C:2]([CH3:10])([CH2:4][CH2:5][C:6](Cl)([CH3:8])[CH3:7])[CH3:3].[Al+3].[Cl-].[Cl-].[Cl-].[C:15]1([CH3:21])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[CH3:21][C:15]1[CH:20]=[CH:19][C:18]2[C:6]([CH3:8])([CH3:7])[CH2:5][CH2:4][C:2]([CH3:10])([CH3:3])[C:17]=2[CH:16]=1

参加物

4

反応物 3

HCID 1140TolueneHCID 80360Hexane, 2,5-dichloro-2,5-dimethyl-HCID 6451240Aluminum(III) Chloride

生成物 1

HCID 811871,2,3,4-Tetrahydro-1,1,4,4,6-pentamethylnaphthalene収率 90%

実験手順

2,5-Dichloro-2,5-dimethylhexane (67.5 g, 0.369 mol) was dissolved in dry toluene (200 ml), and then AlCl3 (4.05 g, 30.4 mmol) was crushed up and added portionwise to the solution. After being left for 2 hours, the reaction mixture was poured into ice/5% HCl and the mixture was extracted with hexane. The organic layer was washed each twice with water, aqueous sodium hydrogen carbonate, and then with water, dried over MgSO4, and the solvent was removed by evaporation. The residue was distilled to give 5,6,7,8-tetrahydro-2,5,5,8,8-pentamethylnaphthalene (70.42 g, yield: 90%). bp 100° C. (solidified at room temperature).

後処理

  1. additionadded portionwise to the solution
  2. extractionthe mixture was extracted with hexane
  3. washThe organic layer was washed each twice with water, aqueous sodium hydrogen carbonate
  4. dry with materialwith water, dried over MgSO4
  5. customthe solvent was removed by evaporation
  6. distillationThe residue was distilled

出典と根拠

ORDレコード
ord-761b847cf8e74abd96bbc3c1bb21f911
出典データセット
uspto-grants-1997_07
特許番号
US05652232

関連ノート

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