Ethanol → Dimaprit hydrochloride
反応式
[ClH:1].[Cl:2][CH2:3][CH2:4][CH2:5][N:6]([CH3:8])[CH3:7].[NH2:9][C:10]([NH2:12])=[S:11].C(O)C>C(OCC)(=O)C>[ClH:2].[ClH:1].[CH3:7][N:6]([CH3:8])[CH2:5][CH2:4][CH2:3][S:11][C:10](=[NH:9])[NH2:12]参加物
5
実験手順
A mixture of 1-chloro-3-(dimethylamino)propane hydrochloride (200 g), thiourea (98.1 g) and ethanol (11) was stirred and heated under reflux for 25 hours. The solution was cooled to ambient temperature and ethyl acetate added until permanent opalescence was obtained. The mixture was stored at 4° C. overnight then filtered to give S-[3-(dimethylamino)propyl]isothiourea dihydrochloride as a colourless solid. (283 g), m.p. 155°-159° C.
後処理
- temperatureheated
- temperatureunder reflux for 25 hours
- customwas obtained
- filtrationthen filtered
出典と根拠
- ORDレコード
- ord-46b82e97efc7465abd875062f6e51b31
- 出典データセット
- uspto-grants-1997_07
- 特許番号
- US05652271
反応ノート
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