Thiourea → SKF 91488 dihydrochloride
反応式
[ClH:1].[Cl:2][CH2:3][CH2:4][CH2:5][CH2:6][N:7]([CH3:9])[CH3:8].[NH2:10][C:11]([NH2:13])=[S:12]>C(O)C>[ClH:2].[ClH:1].[CH3:8][N:7]([CH3:9])[CH2:6][CH2:5][CH2:4][CH2:3][S:12][C:11](=[NH:10])[NH2:13]参加物
4
実験手順
A stirred mixture of 1-chloro-4-(dimethylamino)-butane hydrochloride (115 g), thiourea (51.9 g) and ethanol (500 ml) was heated under reflux for 24 hours then allowed to stand at 4° C. for 24 hours. The resulting solid was collected by filtration, washed with ether, and dried in vacuo at ambient temperature for 24 hours to give S-[4-(dimethylamino)butyl]isothiourea dihydrochloride as an off-white solid (140 g), m.p. 179°-182° C.
後処理
- temperaturewas heated
- temperatureunder reflux for 24 hours
- filtrationThe resulting solid was collected by filtration
- washwashed with ether
- customdried in vacuo at ambient temperature for 24 hours
出典と根拠
- ORDレコード
- ord-d9af7b8f004b473ca776ff809fda7fc3
- 出典データセット
- uspto-grants-1997_07
- 特許番号
- US05652271
反応ノート
読み込み中…