化工社化工社 化学情報印刷レポート · 研究参考用
Chloroacetyl chloride → 4-Chloroacetamido-3-hydroxypyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Chloroacetyl chloride | HCID 6577 | — |
| 反応物 | 4-Amino-3-hydroxypyridine | HCID 2762419 | — |
| 生成物 | 4-Chloroacetamido-3-hydroxypyridine | HCID 19031663 | — |
反応手順
A solution of 4-amino-3-hydroxypyridine (7 g, 0.06 mol) and chloroacetyl chloride (50 ml) was refluxed for 2 hours, cooled and the excess solvent was removed by vacuum distillation. The crude material was dissolved in water, neutralized with Na2CO3 and the solid precipitated filtered and air dried to give the desired product, m.p. 155°-158° C. The structural assignment was supported by the proton NMR spectrum.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05652363 |
| 出典データセット | uspto-grants-1997_07 |
| ORD ID | ord-0e717692545847bf99de662dd998060e |
| 出典メモ | uspto-grants-1997_07 |