2-Chloro-3-nitropyridine → 2-Methoxy-3-nitropyridine

HRID 266917

反応式

HRID 266917 の反応式
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH3:11][O-:12].[Na+]>CO>[CH3:11][O:12][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1

参加物

4

反応物 2

HCID 796132-Chloro-3-nitropyridineHCID 10942334Sodium Methoxide

生成物 1

HCID 2532192-Methoxy-3-nitropyridine収率 75.2%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

2-Chloro-3-nitropyridine (25 g, 0.157 mol) was suspended in methanol (300 ml) and sodium methoxide (17 g, 0.315 mol) was added. The mixture was refluxed for 2 hr and part of the solvent removed under reduced pressure. The reaction mixture was diluted with water (1 litre) and the precipitate collected by filtration. The white solid obtained was washed with more water and dried under vacuum to give the title compound (18.2 g, 75%). 1H NMR (CDCl3): 8.42 (dd, J=5, 2 Hz, 1H); 8.28 (dd, J=8, 2 Hz, 1H); 7.06 (dd, J=8, 5 Hz, 1H); 4.13 (s, 3H)

後処理

  1. temperatureThe mixture was refluxed for 2 hr
  2. custompart of the solvent removed under reduced pressure
  3. additionThe reaction mixture was diluted with water (1 litre)
  4. filtrationthe precipitate collected by filtration
  5. customThe white solid obtained
  6. washwas washed with more water
  7. customdried under vacuum

出典と根拠

ORDレコード
ord-686066c2b0da44208fe1b4661a3551e5
出典データセット
uspto-grants-1997_07
特許番号
US05652363

関連ノート

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