Ethylamine → Benzenamine, 4-chloro-N-ethyl-2-nitro-
反応式
Cl[C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[CH2:12]([NH2:14])[CH3:13]>C(O)C>[CH2:12]([NH:14][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10])[CH3:13]参加物
4
実験手順
A mixture of 26 g of 2,5-dichloro-nitrobenzene, 400 ml of ethanol and 25 ml of ethylamine was refluxed for 24 hours while adding 5 ml of ethylamine at 6 hour intervals and the mixture was cooled and filtered. The orange needles were washed with a small amount of an ethanol-ether mixture and dried over P2O5 under vacuum to obtain 24.4 g (89% yield) of N-ethyl-4-chloro-2-nitro-aniline melting at 90°-91° C.
後処理
- temperaturewas refluxed for 24 hours
- temperaturethe mixture was cooled
- filtrationfiltered
- washThe orange needles were washed with a small amount of an ethanol-ether mixture
- dry with materialdried over P2O5 under vacuum
出典と根拠
- ORDレコード
- ord-b590f27dd45e4daebcaa150698debc92
- 出典データセット
- uspto-grants-1979_04
- 特許番号
- US04151280
反応ノート
読み込み中…