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Dicyclohexylcarbodiimide → N2 [3(S)-amino-2(R)-hydroxy-4-phenylbutyl]-N1 tert.butyl-L-prolinamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 反応物 | Benzyloxycarbonyl-L-phenylalanine | HCID 70878 | — |
| 反応物 | (S)-1-(tert-Butyl)pyrrolidine-2-carboxamide | HCID 54424267 | — |
| 反応物 | HCID 178418300 | HCID 178418300 | — |
| 生成物 | N2 [3(S)-amino-2(R)-hydroxy-4-phenylbutyl]-N1 tert.butyl-L-prolinamide | HCID 86746262 | — |
反応手順
In a manner analogous to that described in Example 92, from 0.15 g of N-(benzyloxycarbonyl)-L-phenylalanine, 0.066 g of hydroxybenzotriazole, 0.1 g of dicyclohexylcarbodiimide and 0.166 g of N2 -[3(S)-amino-2(R)-hydroxy-4-phenylbutyl]-N1 -tert.butyl-L-prolinamide there was obtained 0.1 g of N2 -[3(S)-[N-(benzyloxycarbonyl)-L-phenylalanyl]amino]-2(R)-hydroxy-4-phenylbutyl]-N1 -tert.butyl-L-prolinamide as a white solid of melting point 78°-80° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05652369 |
| 出典データセット | uspto-grants-1997_07 |
| ORD ID | ord-996134842f8f44b3a7e447ea17cd43ed |
| 出典メモ | uspto-grants-1997_07 |