化工社化工社 化学情報印刷レポート · 研究参考用
2-Naphthoyl chloride → 3-cyano-N-(2-naphthoyl)-L-alanine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Naphthoyl chloride | HCID 75246 | — |
| 反応物 | 3-cyano-L-alanine | HCID 439742 | — |
| 溶媒 | Sodium Hydroxide | HCID 14798 | — |
| 生成物 | 3-cyano-N-(2-naphthoyl)-L-alanine | HCID 53874508 | 18.3% |
反応手順
0.114 g of 3-cyano-L-alanine was dissolved in 5 ml of 1N sodium hydroxide solution and treated with 0.285 g of 2-naphthoyl chloride at 0° C. After acidification with 2M hydrochloric acid and flash chromatography on silica gel using 25% methanol in dichloromethane for the elution there was obtained 0.049 g of 3-cyano-N-(2-naphthoyl)-L-alanine of melting point 95°-100° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05652369 |
| 出典データセット | uspto-grants-1997_07 |
| ORD ID | ord-6b76bce827a842f5a4d4e820d568166d |
| 出典メモ | uspto-grants-1997_07 |